A plethora of evidence suggests that melanocortins possess a protective activity in a variety of kidney diseases in both rodent models and human patients. Melanocortin peptides, melanocortin receptors, melanocortin receptor accessory proteins, and endogenous antagonists of melanocortin receptors are the key components constituting the melanocortin hormone system, one of the most complex and important hormonal systems in our body. Division of Nephrology, Department of Medicine, University of Toledo College of Medicine, Toledo, OH, United States.Mingyang Chang, Bohan Chen, James Shaffner, Lance D.
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